Orchestrating Care (and robotic surgery) for Prostate Cancer - Mayo Clinic, FREE book offer – Mayo Clinic Health Letter, Prostate cancer - Does PSA level affect prognosis, Advertising and sponsorship opportunities. For men in their 50s or younger, a PSA level should be below 2.5 in most cases. Easy to Put On, Hard to Lose: Why Am I Overweight?

I had water and blood tests, and have a bladder infection, and a PSA of 70. My second cycle would be restarted at a PSA level of 2.5 ng/ml. P.s had to retire to look after my disabled or I'd still be working now.

So a PSA level of 117 ng/ml is definitely not a good thing. The drop in your PSA count from nearly 3,500 down to 16 ng/ml over a 12-month period basically means only that your cancer is producing less PSA. Overall survival was associated with Gleason score and age at diagnosis.

Having said all that, the decision as to whether you wish to have treatment or not is up to you.

I’ve recommended he not go online about this issue, as a lot of information will not apply to his case, and will probably just cause him to worry. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.

Does this make sense? Talk to your doctor about what this might mean. A bone scan and a CT scan yesterday revealed no metastatic spread other than a possible extension into my bladder. All rights reserved.

Sitemaster has covered a lot of important points. It is extremely unusual for anyone to have a PSA of 500 ng/ml or higher, 12/12 positive biopsy cores, and a Gleason score of 8 and NOT to have evident, metastatic prostate cancer on a bone scan or a CT scan. As a veteran member of this overall group (PSA 113.6 at diagnosis), I am quite familiar with this territory. Started chemo June (docetaxel) by July psa 41. It is also quite certainly true that standard therapy for a man with this diagnosis is combination therapy with both androgen deprivation therapy (ADT, also known as “hormone therapy”) and radiation therapy to the prostate itself and to the surrounding pelvic tissues. Now this one guy psa is 55, and he is looking better. It is possible but very unusual for a man with a PSA level of 200 ng/ml not to have metastatic prostate cancer (i.e., cancer that has spread or is spreading to other organs, most commonly the skeletal bones), but it also might not be widespread yet. Are there other scan types that are more accurate and effective in identifying the propagation of the disease? Hoffman RM. His next appointment with the urologist is coming up. does anyone know what the highest PSA level is? I can see no need at present for any other form of whole body scan. Now I just received a reading of 249 and am wondering if anyone else has experience with this ? Well obviously a PSA of 300 ng/ml is not good and it does strongly suggest a diagnosis of prostate cancer. We haven’t posted any of your comments to date because, bluntly, your arrogance appears to far outweigh anything useful you have written. Metastatic Prostate Cancer Survival Related to PSA Drop After Treatment.

In other words the statement in your third paragraph is wrong (based on the findings in this article). Even without any prostate problems, your PSA level can go up gradually as you age. Am I under-estimating the situation?

He may call this your "PSA velocity." It appears I have been cured by radiation plus ADT in 2013 as my recent PSAs have all been < 0.01.

On the other hand, that history is before the impact of a slew of new drugs designed to help men with advanced cases, and we already know that those drugs are making a substantial difference. However, the PSA test was first developed only to monitor men who had a history of prostate cancer. I am going for an MRI next week. Jan would likely be a helpful resource for you in “thinking through” what you and your husband need to do over time. If you are on or thinking about active surveillance (AS) as a way to manage your low-risk prostate cancer, you may want to join Prostate Cancer International’s Active Surveillance Virtual Support Group.

Frequent sex: Does it protect against prostate cancer? In the past, most doctors considered PSA levels of 4.0 ng/mL and lower as normal.

They can go up and down for no obvious reason.

Jan’s husband had a PSA level in the thousands and extensive metastatic disease when he was diagnosed at age 58, but he lived for another 13 years. I feel great, am healthy in all other aspects. It seems likely that most men with such high PSAs would soon be on some form of androgen deprivation therapy. Accessed July 6, 2017. Eventually, the body becomes resistant to the drug.

Standard treatment for spreading prostate cancer is to give a man a drug that blocks male hormones. That was the criterion for inclusion in the evaluation! We know it’s a worrying time for people with cancer, we have information to help. Hopefully there would be less evidence of metastasis now than when you were first diagnosed. Yes. International prostate cancer registry initiated in Australasia, Early data on efficacy, safety of PSMA-linked lutetium-177, Long-term use of 5-ARIs in low-risk men on AS, Onvansertib in treatment of abiraterone-resistant mCRPC, SBRT vs. EBRT in treatment of painful spine metastases, Breakthrough Device Designation for miR Sentinel™ urine test, Real-world survival benefit of treatment with sipuleucel-T, The problems genital shrinkage causes, and the distress that results. At age 74 and with PSA level of 200, what is the chance of survival.? Wein AJ, et al., eds.

Also, the really important questions are going to be (a) just how low your PSA gets to; (b) how low your serum testosterone level gets to; (c) how long they both stay at those lowest levels before they start to rise again; and then, when your PSA does start to risk again (which it almost certainly will), (d) how fast it does that — known as the PSA doubling time.

My urologist assured me that the tests can be preserved for “future” [IVF] use. WebMD does not provide medical advice, diagnosis or treatment. A PSA test is a test that measures the levels of the protein in the blood. I am thinking about starting a real blog, where there is no deleting anyone’s comment. … I freaked a bit when he was really straightforward with me and told me I should have about 5 years to go if I have the big C and all else fails … wow ….

Until now, there's been no reliable way to tell a patient which group he's in. On the other hand, it is possible he is not explaining everything as well as you may need things explained. My suggestion would be that, depending on where you live, you should go and get a second opinion from a medical oncologist who specializes in the treatment of prostate cancer at a specialist prostate cancer center. Thoughts? From what I’ve read, it’s very likely that it is cancer. If you have been diagnosed with prostate cancer and are concerned about your prognosis, discuss your situation with your doctor. There are now many forms of treatment for Stage IV prostate cancer, but we also have very limited information about the actual ability to significantly extend the survival of such patients beyond 3 to 4 years. That's why doctors watch your results over time instead of focusing on one test result. The findings could also provide what the researchers call a "window of opportunity" to test new treatments for advanced prostate cancer. In another recent paper in BJU International, Ang et al.

I think we need to very clear with you that you are almost certainly have very high-risk prostate cancer that is either evidently metastatic (already spread to your bones or other organs) or at least micrometastatic (spread way beyond your pelvis but not yet visible on a bone scan or a CT scan), and that you are going to need treatment that will be designed to manage your life expectancy. my husbands PSA was 120 on diagnosis and we thought that was high, but I have read about higher. However, what may need to be done is going to depend on some more detailed tests and the results of those tests.

"These findings could help patients avoid ineffective treatment.". They do have a big advantage in being relatively inexpensive, and a lot of useful research is based on their use. My PSA count was 3,499+ ng/ml at diagnosis. So do most prostate cancer cells. My first ever PSA (I had to insist) was 113.6 ng/ml 19.5 years ago, and later evidence suggesting PSA doubling every 3 to 4 months; I had an advantage in that imaging never revealed a metastasis. As for survival, it is outstanding these days for men who do not have metastases at the time of diagnosis — virtually the same as for age-mates who do not have cancer. He is encouraging me to take injections for hormone therapy and radiation treatment but says there is no cure for me. By March 1581 went onto hormone therapy (decapeptyl).

Of course this group was dominated by men who had a PSA that was > 100 at diagnosis.

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Just wanted to know if anyone else has a Psa over 1,000. The longer the PSA doubling time when it does start to rise, the better. Er bestaan bepaalde soorten agressieve prostaatkanker waarbij PSA waarden geenzins verhoogd zijn. Sorry so many questions, as it's a worrying time. Still looking well but the odd blip. I later had radiation (in 2013), and my labs and exams suggest I have been cured.

There are no formal “guidelines” as to what and when we are willing to post as comments. I, of course, am very worried, and wonder if his prognosis is as bleak as it appears from my limited perspective. … Am still rather fit but slightly overweight, say 5 kg. I am also on a strict diet of no meat, potato, rice, bread, and basically all starches. Two years ago my PSA was 44. PSA is a protein made by prostate tissue. Aug. 29, 2006 -- How long will a man with advanced prostate cancerprostate cancer survive? Sitemaster – One of the reasons I find this blog so helpful is the responses you provide as they help me think. Sign Up to Receive Our Free Coroanvirus Newsletter, Prostate Cancer's Link to Bone Metastasis, Prostate Cancer: Frequently Asked Questions, Join the Discussion in the Prostate Cancer Community, Slideshow: A Visual Guide to Prostate Cancer, Prostate Cancer Treatment: How to Handle the Side Effects, Prostate Cancer Clinical Trial: What to Expect. Those with undetectable PSA levels have only one-fifth the risk of death as men with higher PSA levels. Therefore, if a man had a PSA level above 4.0 ng/mL, doctors would often recommend a prostate biopsy to determine whether he had prostate cancer. People can live with prostate cancer for years after a diagnosis like this — and it is possible that it isn’t even prostate cancer (although not very likely). I think you will be much more knowledgeable after you have the results of the MRI scan. Urology Care Foundation: "Prostate Cancer Testing," "Advanced Prostate Cancer. It is quite certainly true that you have AJCC Stage IV prostate cancer (or at least clinical stage T3-4NxM0). My first-ever PSA in December 1999 was 113.6 (with a Lupron flare and/or growth to 125 two weeks later).

Orchestrating Care (and robotic surgery) for Prostate Cancer - Mayo Clinic, FREE book offer – Mayo Clinic Health Letter, Prostate cancer - Does PSA level affect prognosis, Advertising and sponsorship opportunities. For men in their 50s or younger, a PSA level should be below 2.5 in most cases. Easy to Put On, Hard to Lose: Why Am I Overweight?

I had water and blood tests, and have a bladder infection, and a PSA of 70. My second cycle would be restarted at a PSA level of 2.5 ng/ml. P.s had to retire to look after my disabled or I'd still be working now.

So a PSA level of 117 ng/ml is definitely not a good thing. The drop in your PSA count from nearly 3,500 down to 16 ng/ml over a 12-month period basically means only that your cancer is producing less PSA. Overall survival was associated with Gleason score and age at diagnosis.

Having said all that, the decision as to whether you wish to have treatment or not is up to you.

I’ve recommended he not go online about this issue, as a lot of information will not apply to his case, and will probably just cause him to worry. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.

Does this make sense? Talk to your doctor about what this might mean. A bone scan and a CT scan yesterday revealed no metastatic spread other than a possible extension into my bladder. All rights reserved.

Sitemaster has covered a lot of important points. It is extremely unusual for anyone to have a PSA of 500 ng/ml or higher, 12/12 positive biopsy cores, and a Gleason score of 8 and NOT to have evident, metastatic prostate cancer on a bone scan or a CT scan. As a veteran member of this overall group (PSA 113.6 at diagnosis), I am quite familiar with this territory. Started chemo June (docetaxel) by July psa 41. It is also quite certainly true that standard therapy for a man with this diagnosis is combination therapy with both androgen deprivation therapy (ADT, also known as “hormone therapy”) and radiation therapy to the prostate itself and to the surrounding pelvic tissues. Now this one guy psa is 55, and he is looking better. It is possible but very unusual for a man with a PSA level of 200 ng/ml not to have metastatic prostate cancer (i.e., cancer that has spread or is spreading to other organs, most commonly the skeletal bones), but it also might not be widespread yet. Are there other scan types that are more accurate and effective in identifying the propagation of the disease? Hoffman RM. His next appointment with the urologist is coming up. does anyone know what the highest PSA level is? I can see no need at present for any other form of whole body scan. Now I just received a reading of 249 and am wondering if anyone else has experience with this ? Well obviously a PSA of 300 ng/ml is not good and it does strongly suggest a diagnosis of prostate cancer. We haven’t posted any of your comments to date because, bluntly, your arrogance appears to far outweigh anything useful you have written. Metastatic Prostate Cancer Survival Related to PSA Drop After Treatment.

In other words the statement in your third paragraph is wrong (based on the findings in this article). Even without any prostate problems, your PSA level can go up gradually as you age. Am I under-estimating the situation?

He may call this your "PSA velocity." It appears I have been cured by radiation plus ADT in 2013 as my recent PSAs have all been < 0.01.

On the other hand, that history is before the impact of a slew of new drugs designed to help men with advanced cases, and we already know that those drugs are making a substantial difference. However, the PSA test was first developed only to monitor men who had a history of prostate cancer. I am going for an MRI next week. Jan would likely be a helpful resource for you in “thinking through” what you and your husband need to do over time. If you are on or thinking about active surveillance (AS) as a way to manage your low-risk prostate cancer, you may want to join Prostate Cancer International’s Active Surveillance Virtual Support Group.

Frequent sex: Does it protect against prostate cancer? In the past, most doctors considered PSA levels of 4.0 ng/mL and lower as normal.

They can go up and down for no obvious reason.

Jan’s husband had a PSA level in the thousands and extensive metastatic disease when he was diagnosed at age 58, but he lived for another 13 years. I feel great, am healthy in all other aspects. It seems likely that most men with such high PSAs would soon be on some form of androgen deprivation therapy. Accessed July 6, 2017. Eventually, the body becomes resistant to the drug.

Standard treatment for spreading prostate cancer is to give a man a drug that blocks male hormones. That was the criterion for inclusion in the evaluation! We know it’s a worrying time for people with cancer, we have information to help. Hopefully there would be less evidence of metastasis now than when you were first diagnosed. Yes. International prostate cancer registry initiated in Australasia, Early data on efficacy, safety of PSMA-linked lutetium-177, Long-term use of 5-ARIs in low-risk men on AS, Onvansertib in treatment of abiraterone-resistant mCRPC, SBRT vs. EBRT in treatment of painful spine metastases, Breakthrough Device Designation for miR Sentinel™ urine test, Real-world survival benefit of treatment with sipuleucel-T, The problems genital shrinkage causes, and the distress that results. At age 74 and with PSA level of 200, what is the chance of survival.? Wein AJ, et al., eds.

Also, the really important questions are going to be (a) just how low your PSA gets to; (b) how low your serum testosterone level gets to; (c) how long they both stay at those lowest levels before they start to rise again; and then, when your PSA does start to risk again (which it almost certainly will), (d) how fast it does that — known as the PSA doubling time.

My urologist assured me that the tests can be preserved for “future” [IVF] use. WebMD does not provide medical advice, diagnosis or treatment. A PSA test is a test that measures the levels of the protein in the blood. I am thinking about starting a real blog, where there is no deleting anyone’s comment. … I freaked a bit when he was really straightforward with me and told me I should have about 5 years to go if I have the big C and all else fails … wow ….

Until now, there's been no reliable way to tell a patient which group he's in. On the other hand, it is possible he is not explaining everything as well as you may need things explained. My suggestion would be that, depending on where you live, you should go and get a second opinion from a medical oncologist who specializes in the treatment of prostate cancer at a specialist prostate cancer center. Thoughts? From what I’ve read, it’s very likely that it is cancer. If you have been diagnosed with prostate cancer and are concerned about your prognosis, discuss your situation with your doctor. There are now many forms of treatment for Stage IV prostate cancer, but we also have very limited information about the actual ability to significantly extend the survival of such patients beyond 3 to 4 years. That's why doctors watch your results over time instead of focusing on one test result. The findings could also provide what the researchers call a "window of opportunity" to test new treatments for advanced prostate cancer. In another recent paper in BJU International, Ang et al.

I think we need to very clear with you that you are almost certainly have very high-risk prostate cancer that is either evidently metastatic (already spread to your bones or other organs) or at least micrometastatic (spread way beyond your pelvis but not yet visible on a bone scan or a CT scan), and that you are going to need treatment that will be designed to manage your life expectancy. my husbands PSA was 120 on diagnosis and we thought that was high, but I have read about higher. However, what may need to be done is going to depend on some more detailed tests and the results of those tests.

"These findings could help patients avoid ineffective treatment.". They do have a big advantage in being relatively inexpensive, and a lot of useful research is based on their use. My PSA count was 3,499+ ng/ml at diagnosis. So do most prostate cancer cells. My first ever PSA (I had to insist) was 113.6 ng/ml 19.5 years ago, and later evidence suggesting PSA doubling every 3 to 4 months; I had an advantage in that imaging never revealed a metastasis. As for survival, it is outstanding these days for men who do not have metastases at the time of diagnosis — virtually the same as for age-mates who do not have cancer. He is encouraging me to take injections for hormone therapy and radiation treatment but says there is no cure for me. By March 1581 went onto hormone therapy (decapeptyl).

Of course this group was dominated by men who had a PSA that was > 100 at diagnosis.

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